Before any dose
1. Ask for a real medical screen.
“Medical screening” should mean more than a questionnaire. A safety-focused program should explain what it reviews, who reviews it, what findings change eligibility, and when it refers someone for further care.
ECG and cardiac history
Ask whether a recent ECG is required and how the result is interpreted before treatment. A cardiac history should account for known rhythm problems, fainting, structural heart disease, family history, and current symptoms.
This matters because long QT syndrome and QT prolongation are associated with a risk of dangerous arrhythmias; a center should not present heart screening as a ceremonial formality.
Electrolyte labs
Ask which laboratory tests are used, how recent they must be, and whether abnormal electrolytes are corrected and rechecked before proceeding. Potassium and magnesium can be relevant to cardiac electrical stability.
A clear answer should include what happens when labs are abnormal, rather than a generic statement that testing is available.
Medication and substance review
Ask for a careful review of prescribed medicines, over-the-counter products, supplements, and recent substance use. Interactions, withdrawal, sedation, and cardiac effects can all affect risk.
The FDA’s drug-interaction safety information reflects a basic principle: medication decisions should be reviewed in context, not reduced to a one-size-fits-all stop list.
Contraindications and deferral
Ask which medical and psychiatric circumstances lead the program to decline or defer treatment. A credible answer should acknowledge that some people may not be appropriate candidates and that uncertainty may require outside evaluation.
For comparison, program-level treatment information can help frame the questions, but it should never substitute for an individualized clinical review.